医药高科技发明专利治疗各类癌症药物组合及制备方法用途简介
Patent of medical science and technology: A brief introduction on the preparation method and application of a composite formula of anti-carcinogens
Specific interviews are needed for cooperation of developing or patent transfer. Jingzhou Weng, Home Phone: 0576-83803935, Telephone: 13867629238, Address: No. 4 East River Bank Road, Tiantai County, Zhejiang Province (Room 401)
本发明经过中华人民共和国国家知识产权局依照中华人民共和国专利法进行审查，专利申请日2008年4月18日，授权公告日2011年6月29日，决定授予专利，颁发证书，依法授权登记，获四项发明专利。
The present invention has been censored by State Intellectual Property Office of the People's Republic of China according to Patent Law of the people's Republic of China. Patent application date: April 18
th, 2008. Authorized announcement date: June 29
th , 2011. The decision to grant a patent, issue a certificate and authorize registration according to the law has been made. And the invention has awarded four patents.
一、本发明涉及一种中草药组合物，具体地说是涉及一种治疗癌症的药物组合物，其制备方法及其用途:
1. The present invention involves a composite of Chinese herbal medicine, specifically relates to a pharmaceutical composition for the treatment of cancer, and its preparation method and application are introduced as follows:
l、一种治疗癌症的药物组合物，其特征在于二十五味合成原料所产生的治癌特性，重量配比合成。
1.1 A composition of anti-carcinogens characterized by the anticancer property produced by twenty-five ingredients which have been synthesized via weight proportioning synthesis.
2、根据权利要求2所述的治疗癌症的药物组合物的制备方法，初加工程序，进入精加工程序，析出精结晶，将精结晶装入胶囊，制成胶囊药物制品。
1.2 The production process of the capsule drug include initial processing, fine processing, precipitated fine crystallization, and capsule preparation, according to the preparation methods stated in Claim 2 of the corresponding patent of the composite formula of anti-carcinogens.
3、根据权利l所述的治疗癌症的药物组合物的用途，制备抗癌肿瘤临床应用。
.3 The clinical applications of the composite formula of anti-carcinogens are determined according to the functions of this formula clarified in Claim 1.
4、本发明优选组合，设计三种剂型，十种药物组合，分别治疗各类癌症。
1.4 Optimization of the composition, designation of three forms of the drug involving ten combinations of different drugs to treat various cancers have been introduced in the invention.
本人出生在八代民间医学世家，十七岁从医，68年拜北宗张松溪门下静清师学习内丹、医药、武术。71年拜全真南宗一代宗师谢崇根学习内丹武功医学，成为二十七代谪传传人，内丹、武功、医学造诣颇深。总结了肿瘤治疗方面的经验。四十多年来对肿瘤病因病机进行探讨的同时，总结了肿瘤治疗方面的经验，使之日臻完善。恶性肿瘤是严重危害人类健康和生命的一类常见疾病，对于肿瘤治疗是世界上医学难题，目前除了手术、放疗、化疗及近年引进美国最新技术设备的热疗方法等西医疗法，中医中药及中西医相结合治疗方法被医学界广泛关注和重视。“清癌丹”以“还魂草”、“灵芝仙草”、“络石”等为主配制和合二十五味中草药合制而成，从以毒攻毒、攻克癌症、扶正祛邪和辨证施治。对肿瘤具有抑制及根治效果。中医中药博大精深，自成体系，阴阳理论，长盛不衰。在继承中医清热解毒理论基础上，大胆探索，勇于实践，去其糟粕，取其精华。在反复实践中发明了一种中草药治疗癌症的药物配方，利用现代高科技，引进国际最先进设备，经过精加工，提取的药物，被命为“清癌丹”。
The inventor was born in a family of Chinese traditional medicine for eight generations, who started medical practice at the age of seventeen, studied inner alchemy, medicine and martial arts under the supervision of Song-xi Zhang in the Northern Faction since 1968, and later studied inner alchemy, martial arts and medicine from the master of Southern Faction of Quanzhen, Chong-gen Xie since 1971, becoming the twenty-seventh generation direct descendant being proficient in inner alchemy, martial arts and Chinese medicine. The inventor has made great efforts in investigation of tumorous etiology and pathogenesis, as well as the summary of the experience of cancer treatment which has been greatly improved. Malignant tumors are a common category of disease threatening human health and life, and the treatment of tumors is still a major difficulty around the world. Except surgeries, chemotherapy, radiotherapy and recent introduction of thermotherapy from USA with the latest technology and equipment, Chinese medicine and herbals, as well as the combination of traditional Chinese and Western Medicine to treat diseases have been paid much attention in the medical field. The anti-cancerous alchemical medicine, “Qing’ai Dan”, consisting of “whorlleaf stonecrop herb”, “lucid ganoderma”, “tracheloside” and other twenty-five Chinese herbal medicine, exerts its functions based on the principles such as “like cures like”, anti-cancer , strengthening body resistance to dispel pathogenic factors, syndrome differentiation and treatment, for the inhibition and radical treatment of tumors. Chinese medicine covers broad aspects with profound knowledge and theories, and it is self-contained based on the Yin-Yang theory and remain on the glory trail for long years. On the basis of inheriting the theory of detoxification in traditional Chinese medicine, the inventor developed a herbal composite formula to treat cancers through bold exploration and repeated practice to take the essence to its dregs, using modern technology and the advanced equipment at the international level, and the refined medicine is called “Qing’ai Dan”.
二、世界癌症发病率成倍增加己严重危害人类健康，癌症严重地危害着人类健康，引起世界人民的关注，据世界卫生组织统计全球近70亿人口中，发病率1200万人左右死亡800余万人，约占人数的10%，500余万人发生在发展中国家，并且每年以5%的速度增加。
2. The incidence of cancer in the world has increased exponentially, threatening human health and drawing much attention of people internationally. According to the statistics of the World Health Organization, the cancer population has reached 12,000,000 among approximate 7,000,000,000 people in the whole world, and the mortality is more than 8,000,000, accounting for 10% of the global population. And in developing countries, more than 5,000,000 have cancers and the number is increasing by 5% of the population per year.
1、食品中有毒成分增加。2、空气污染:空气中有害气体排放，有害气体增加，危害身体健康。3、饮用水质降低:水资源污染，饮用水质降低，有毒有害成分增加。
4、长期隐性慢性疾病病变致癌。5、遗传基因致癌。 (以上五种致癌物质于1998年发表在 《医学新进展》一书中。科学家以发现ROUS肉瘤病毒基因，有一种编码酪氨酸蛋白激酶的基因，并已证实在人体细胞中起到关键作用，同时己发现正常有效细胞在一定情况下向癌变转化基因，因为这一基因来自病毒，被命名为病毒癌基因。
2.1 The toxic components have increased in foods.
2.2 Air pollution: the discharge and increase of harmful gases in the air threaten the health of people.
2.3 Reduced quality of the drinking water: water pollution, decreased drinking water quality, increased toxic and harmful components.
2.4 Long-term latent chronic diseases are carcinogenic.
2.5 Genetic carcinogenesis.
The above five carcinogenic factors were introduced in the book of
New Advances in Medicine published in 1998. The scientists have found a gene encoding tyrosine protein kinase in the genome of ROUS sarcoma virus and confirmed its key role in the human cells. They also found that normal cells could transform into cancer cells via genetic changes. Since the gene derives from virus, thus it is named viral oncogene.
三、一种治疗癌症的中草药合成配方“清癌丹”。治疗各类癌症:“清癌丹”以还魂草、灵芝草、络石和合二十五味中草药合制而成，“清癌丹”药物配方组成继承中华中医阴阳学说理论，辨证施治法理原则，利用现代高科技设备，通过精加工提取。 “清癌丹”主治:肝癌、脑癌、乳腺癌、食道癌、淋巴癌、胃癌、子宫癌、皮肤癌、鼻咽癌、直肠癌及各类癌症。
3. The herbal formula of “Qing’ai Dan” for the treatment of cancers
The “Qing’ai Dan” consists of “whorlleaf stonecrop herb”, “lucid ganoderma”, “tracheloside” and other twenty-five Chinese herbal medicine based on the “Yin-Yang” theory in traditional Chinese medicine and the principle of syndrome differentiation and treatment using modern high-tech and equipment through refinement processing. Indications of “Qing’ai Dan”: liver cancer, brain cancer, breast cancer, esophageal cancer, lymphoma, gastric cancer, uterine cancer, skin cancer, nasopharyngeal carcinoma, colorectal cancer and other various types of cancer.
还魂草 Come back Agrimonia 别名江南卷柏、石柏、岩柏草、九死还魂草、黄疽卷柏。为卷柏科植物江南卷柏 Selaginellamoellendorfii Hieron的全草。
Come back Agrimonia, also known as Selaginella moellendorfii, Doederlein's Spikemoss Herb, Rock Cypress Herb, Resurrection Herb, Selaginella jaundice, is a kind of entire plants of Selaginellamoellendorfii Hieron.
采集还魂草也称九死还魂草，就其药名也就显示出其特殊的生命力。它长时期生长在我国仙山浙江天台山旅游胜地华顶、石梁、寒石山、佛道圣地翠屏山、九遮山、南海普陀山、仙居深山、温州雁荡山、江西龙虎山、湖北武当山、四川峨眉山、台湾、福建、广东等地，其生活习性喜高山不适宜平原沃野，不怕日晒雨淋，不怕天寒地冻，不怕干旱，死去活来，见水还阳，形状像把伞子，常年郁郁葱葱，可作为盆景欣赏，又是名贵药材。所以道教仙师把这一仙草取名为九死还魂草。代代相传，名载史册。全草全年可采，鲜用或晒干。化学成分含两种醛类成份，别有酚性、酸性及中性物质。性味性平，味徽甘。成分预试全草含生物碱、植物淄醇及皂甙
The alias of come back Agrimonia, Resurrection Herb, indicates its unique vitality. The herb grows in regions including Huading mountains in China Zhejiang Tiantai Mountain Resort, Shiliang, Hanshi mountain, Buddhist shrines Cuiping Mountain, Jiuzhe Mountain, Putuo Mountain in the South Seas, Xianju mountains, Yandang Mountain in Wenzhou City, Mount Longhu in Jiangxi Province, Wudang Mountain in Hubei Province, Mount Emei in Sichuan Province, Taiwan, Fujian Province, Guangdong Province, and it prefers to high mountains rather than fertile plains. It can survive severe conditions such as in hot sun, heavy rain, freezing coldness, extreme drought, and can also revive after damage to death such as in the case that it come back to life after receiving water when dried-up. It is shaped like the umbrella, lush perennial, and can be enjoyed as a bonsai as well as a rare medicinal herb. Hence, Taoism named the the herb as Resurrection herb and its legend has been passed down from generation to generation and listed in the annals of history. The whole plant can be taken throughout the year for use both with fresh or dried come back Agrimonia. Its chemical components mainly include two kinds of aldehyde, and other components are phenol, acidic and neutral species. It has a mild property and tastes a little sweet. The whole plant contains alkaloid, plant catalpol and saponin confirmed by component testing.
药理药性 l、所含生物碱对小白鼠肉瘤SlM有较好抑制作用:给实验性肝癌的小白鼠灌胃，共 12天，但能明显增长动物的生存天数。2、有增强机体代谢和网状内皮系统功能。
Pharmacological properties: 1. The alkaloid contents demonstrated effective inhibition on sarcoma SlM in mouse: lavage in experimental mouse models of liver cancer for 12 days significantly prolonged the survival periods. 2. It can improve the metabolism of the body and the function of reticuloendothelial system.
功能主治抗肿瘤良药，具有控制癌细胞端粒酶和抗黑色肿瘤病毒扩散，清热利尿、活血消肿。用于急性传染性肝炎、肝硬化、肝肿瘤、胸胁腰部挫伤、全身浮肿、血小板减少。药用价值极高，在临床中效果显著。用量25一60。
Functions: It is recommended for cancer treatment, regulating telomerase in cancer cells and functions against the spread of Black tumor virus, and can be used for diuresis and detumescence. It can also be adopted to treat acute infectious hepatitis, liver cirrhosis, liver neoplasms, thoracic and lumbar injury, systemic edema, thrombocytopenia, with high medical values and remarkable clinical effects. Proper dosage ranges from 25 to 60.
从事医学研究四十余年来，治愈各类疾病数以万计，治愈各类癌症数以千计，擅长中医内科，擅长于肿瘤(癌症)治疗，善于运用天台山中草药，从事各类癌症的临床治疗，早期有效率92.8%，效果显著。论文有《癌症克星-紫阴还魂丹》，《天台山仙草黄精药用和延年益寿效果》等论文三十余篇。2000年世界医学大会上，荣获世界医学会金奖，“授予中华特色名医"。2002年世界华陀医学大会上，荣获"华伦医学金奖"，并授予"世界名医"。经济消息报社牌愿:鉴于您在医疗事业中做出突出贡献，在实践"三个代表"的重要思想中，功绩卓越，得到了社会的认同、国家的肯定，被经济消息报社评为最佳新闻人物。治疗癌症理论与务实入编《当代专家论文精选》:2000年入编《世界优秀专家人才大典》
In the medical researches of more than forty years, the inventor has cured thousands of cases of a variety of diseases, in which cancer cases accounting for hundreds. The inventor is proficient in internal medicine of traditional Chinese Medicine and tumor (cancer) treatment using herbs from Tiantai Mountain with an early efficacy of 92.8% suggesting the significant effects of the treatment. The inventor has written more than thirty articles published include
Anti-carcinogen: Ziyin Resurrection Alchemical Medicine, and
The Medical and Life-prolonged Effects of Rhizoma Polygonati of Tiantai Mountain, and received the World Medical Association Gold Award, and awarded as
Chinese characterized important doctor in the World Medical Congress in 2000. Later in 2002, the inventor was awarded
Huatuo Medical Gold Award and the title of
World Famous Doctor in World Huatuo Medical Congress. Economic News noted that “based on your outstanding contributions to the medicine and in the practice of "Three Represents" which has been recognized and affirmed by our society and nation, you are recognized as the best news figure by Economic News’’. The anti-cancerous theory and practice of the inventor have been compiled into
Contemporary Expert Essays and the inventor was listed into
World’s best experts in 2000.
四、恶性肿瘤细胞结构的分析:肿瘤是一种细胞的异常增生，癌变细胞与正常细胞相比，其结构、功能和代谢有着质的区别，它具有超正常的增生能力。这种增生和机体不相协调，非肿瘤性增生与肿瘤性增生不同前者，常有明显的刺激因素，具有增生于一定时间和一定程度，一旦癌变细胞清除即不再增生。如果超越一定限度，即发生质变，也可变为肿瘤性增生，由良性肿瘤转变成恶性肿瘤 (癌)。癌变是一个复杂的、多阶段的过程，多数癌是从单细胞核演变而来。宿主受某些外界化学、物理、生物等因子影响，基因细胞发生改变，形成变异细胞，此阶段称为启动阶段，再受人体各种因素影响，癌症经过促进阶段癌细胞开始形成。并逐步向周边浸润，转移、扩散至其他脏腑，最后危及生命。
4. Structural analysis of malignant tumor cells: Tumor is an abnormal proliferation of cells. The structure, function and metabolism of cancerous cells are different from those of normal cells, for they have excessive capacity of proliferation, which does not coordinate with the body. Non-tumorous proliferation is also different from tumorous proliferation, because the former is commonly induced by definite causes to a certain extent for a self-limited period. Once the cancerous cells are cleared, the non-tumorous proliferation stops. However, when it exceed the limit, which means there is a qualitative change, it can also transform into tumorous proliferation, and the benign tumor becomes a malignant one (cancer). The process of canceration is a complex, multi-staged course, and most of the cancer cells are derived from a single cell with abnormal nucleus. When cells in the host are affected by external chemical, physical or biological factors and the genetic materials changes, they will become abnormal cells and this is called the initial phase. Later, the cells react to various intrinsic factors inside the human body to form cancer cells through promotion phase and gradually invade the surrounding areas, and even metastasize, diffuse to other organs, or cause deaths.
五、清癌丹的特性清除体内癌毒，保护体内有效细胞，提高机体免疫功能:调整阴阳，即调整体内阴阳，人体外属阳，内属阴，气属阳，血属阴。宇宙与人体的关系:东方木利肝，南万火利心，西方金利肺，北方水利肾。脏腑肝与胆互为表里，肺与大肠互为表里，心与小肠互为表里，肾与膀脱互为表里，脾与胃互为表里，还有生理胞(胞宫)人体阴阳失调，疾病发生，某一脏腑阴阳失调，某一脏腑发生病变。用药需洞晓阴阳，深达造化，体内阴阳亦两齐，若还缺一不芳非。癌症发生，体内阴阳严重失调，调整体内阴阳，补气补血，该药组合所产生的合成元素能①调整体内阴阳，②改变体内循环系统，③增强免疫功能，④促进网状内皮系统活力，⑤保护有效细胞，⑥促进癌变细胞基因转变，⑦杀癌抗癌攻克癌症。
5. The properties of Qing’ai Dan
It has the capacity to clear the cancer toxins inside the body, protect the normal cells in the body and improve the body’s immune function: regulation of Yin-Yang refers to the adjustment of Yin-Yang inside the human body with the exterior as Yang and the interior as Yin, qi as Yang and blood as Yin. The relation of the universe and human body: the East indicating wood benefits the liver, the South indicating fire benefits the heart, the West indicating metal benefits the lung, the North indicating water benefits the kidney. In addition, the organs inside the body also relates to each other. The exterior and interior pairs include liver and gallbladder, lung and large intestine, heart and small intestine, kidney and urinary bladder, spleen and stomach, as well as reproductive organs (uterus). Furthermore, disequilibrated Yin-Yang balance results in diseases, and the dysfunctioned Yin-Yang balance in a certain organ results in diseases in the corresponding organ. Thus, the administration of medicine should be conducted according to the Yin-Yang theory and the determination of the underneath changes. The Yin-Yang in the body should be kept in balance, and both of them are prerequisite for a healthy body. The occurrence of cancer suggests the severe imbalance of Yin-Yang in the body, thus regulation is needed to regain a balance, such as enriching the qi and blood. The present composite medicine can produce elements to regulate the Yin-Yang inside the body, adjust the circulation system, enhance the immune function, promote the activity of the reticuloendothelial system, protect normal cells, facilitate the genetic transformation of cancer cells and kill cancer cells.
六、一种治疗癌症的药物商品名“清癌丹”市场开发前景。
6. The market development prospect of an anti-cancer product named “Qing’ai Dan”
道医学植根于中华道德文化，契合于东方哲学，论证理炁科学和理形科学，是突破现代中医学发展瓶颈的重大理论和实践。
脏腑功能概要：五脏是肾、肝、心、脾、肺的合称，共为五脏。道医学研究和把握生命的真相而论五脏，慧观其“藏于内的相”和“形于外的场”从本因、内因、外因这个三因中，以精、炁、神这个根本，并且兼容“有之以为利”而有质有形的五脏器官。以“无形有质”统领“有形有质”，同步进行研究，无形决定着有形，以先天无形统帅后天有形，这就是道医学的灵魂所在。
Taoist medicine is rooted in the traditional Chinese moral culture, according with Oriental philosophy and demonstrating physical science, which is a breakthrough both in theoretical and practical modern Chinese medicine.
A summary of visceral function: the five viscus include Kidney, liver, heart, spleen and lung, and the Taoist medicine involves the investigation of life based on the five viscus, with a wise viewpoint on the exterior and interior phenomenon of the body. The causes of diseases include the inherited, internal and external causes, and the basis includes essence, qi and spirit, as well as the object five viscus which exhibit the symptoms and signs of different diseases. The theory is a cause-effect one, in which the invisible matters rule the visible body, and the synchronous study on both with the core theory that the invisible determines the visible and the congenital invisible rules the acquired visible, is the essence of Taoist medicine.
七、五十年从事医学研究，四十多年从事各类肿瘤癌症研究。
7. Fifty-year’s medical research and more than forty-year’s researches on various cancers
着重点对天台山传统佛道文化，对传统道教医药进行科学研究，并为此付出艰辛努力。道法自然，崇尚自然，清静养生，天与地同参，是道家思想的精髓所在。“清癌丹”治疗癌症研究成果是中国道家历经数千年治病养生服食妙方的延伸。采用高山“还魂草”、“石络莲”、“灵芝草”等几十种纯天然植物中草药配伍，利用现代高科技提炼而成，服用该丹能达到法药相助，使病人始终保持元神健旺·安和五脏，滋润气液。实际生活中，因阴阳失调，元气虚损，髓海空虚而造成的病毒侵入、尤其在消除癌毒及阴阳严重失调和深度疲劳，抗病历降低，体能透支。迅速恢复体能方面有意想不到的神妙效果……。神清则百骸清，神浊而五脏浊，而百病生。病从体内生、体在自然中、心与自然、万物相应。癌毒消除，身体恢复健康。人法地·地法天，天法道，道法自然。在临床研究应用中，采用传统道教医药与现代高科技相结合，研制药物元素合成与临床应用相结合，利用现代高科技手段与道家传统医药和天台山医药走向现代化相结合，在长期研究实践中发现了一种具有顽强生命力的“还魂草”、“石络莲”和道藏记载的以毒攻毒的良药，应用于肿瘤 (癌症)的治疗，并吸取了道家医药和健康长寿的精华，研制一代治疗各类癌症的新药“清癌丹”面世，解决了历代道家宗师没有解决的外丹课题。为中国以至世界治疗癌症开辟了新的途径。
Scientific researches on traditional Taoist medicine based on the traditional Buddhist culture in Tiantai Mountain and great efforts made by the inventor are the main work. Imitation of the nature, advocation of nature, quiet health, and reference to nature are the essence of Taoism. The anti-cancerous “Qing’ai Dan” is an extensive achievement based on treatment regimen recipe which has a long history of thousands of years for Chinese Taoists. It contains “whorlleaf stonecrop herb”, “lucid ganoderma”, “tracheloside” and other several dozens of Chinese herbs from high mountains, via refinement using modern technology and the advanced equipment. This oral taken medicine can help the patients maintain healthy, protect the five viscus and provide nutrition to the blood, especially helpful for those patients who suffer severe Yin-Yang imbalance, weakness, virus invasion, fatigue, reduced immune function, physical overdraft. Clear spirit is also important for it influence the health of the body, and has a major impact on the five viscus when it is damaged and will cause diseases. Since diseases are on the body, and the human bodies are in the natural environment, the mind and the nature as well as all the others in the universe are correlated. When the cancer toxins are cleared, the human body will regain health. Man follows the law of the earth, which takes its law from heaven. Heaven is gotten from the Tao and the law of Tao is mingled with the nature. In the clinical researches, the combination of traditional Taoist medicine and modern high-tech to develop new medicine and promote its application into clinical practice has been adopted by the inventor to produce a composite Chinese medicine from Tiantai Medicine based on the combination of modern high-tech methods and Taoist traditional medicine to a modernized production. And a effective drug consisting of “whorlleaf stonecrop herb”, “lucid ganoderma”, “tracheloside” was invented during a long-term study and practice. It can be used in treatment of tumors (cancers) with advantages of Taoist medicine and life-prolonged essence. The new medicine “Qing’ai Dan” will solve the problem that has never been settled before by previous masters in the field of Taoist external alchemy and may open up new ways for the treatment of cancer in China and even in the world.
一种治疗癌症的药物组合，其制各方法及用途，已获国家专利授权，商品名“清癌丹”的丹药药品投资开发。本发明按照设计优选地组合生产制作10号药物，分别应用于各类癌症，分各阶段不同类别癌症，投入正常生产，形成二条流水线生产。规范开发市场，前景将不可估量，可取得150亿至200亿利润。前景广阔，投资回报率极高，并将取得巨大投资效益。有意投资开发高科技研究发明专利，“清癌丹”十种药物分别治疗各种癌症。该发明专利全权转让或合作共同开发。
This new anti-cancer formulated medicine, with its preparation methods and applications have been approved and granted patents, whose commodity name is “Qing’ai Dan” is waiting for investment and development. This present invention plans to produce 10 composites of medicine according to designation for treatment of different cancers. And the production should be determined according to various stages and various cancers, forming two production lines. If standardized development of market can be implemented, the prospect of this composite will impressive, with an estimated profit of 15,000,000,000 to 20,000,000,000. This is an invention of a considerable prospect and an extremely high mercantile rate of return and is prepared for investment and development as high-tech research and invention patents. The ten drugs of “Qing’ai Dan” are planned to treat different cancers. Specific interviews are needed for cooperation of developing or patent transfer.
